RAB6A — RAB6A, member RAS oncogene family
RAB6A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAB6A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Epithelial junction polarity Migration & adhesion | CXADR, FRMD3, IL13RA1, KIF3B, MARVELD3, NEDD9, PTPRD, SLC41A2 +5 more | View in SCUBA |
| Gamma-delta T cells | Vesicular Trafficking Housekeeping | ADD1, ANAPC5, COPG1, EFCAB14, EXOC7, GANAB, MAN2B2, MCM3AP +10 more | |
| Innate lymphoid cells | ILC1 Lymphocyte Signaling Immune regulation | CDIPT, CNPY3, DBNL, ENG, IL16, LIMD2, LSM2, MAPKAPK3 +11 more | View in SCUBA |
| Macrophages | RAB-mediated Trafficking Vesicular traficking | ABI1, ACSL3, ARMC8, CACUL1, CD86, CHST15, CRTC3, CTNNA1 +27 more | View in SCUBA |
About the gene
| Synonyms | RAB6 |
|---|---|
| Chromosome | 11: 73675638-73761137 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | ER-Golgi transport, Host-virus interaction, Protein transport, Transport |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Recruits VPS13B to the Golgi membrane. Plays a role in neuron projection development (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.