Chromatin Epigenetic Regulation
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 33 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 33 genes have a known function matching the annotation |
Why this annotation
The top hub genes and most of the module are chromatin regulators: KMT2C (H3K4 methyltransferase), KDM4C (H3K9/K36 demethylase), ASH1L (H3K36 methyltransferase), KAT6A (H3K9 acetyltransferase), NIPBL (cohesin loading, chromatin organization), PHF3 (transcription elongation/chromatin), HUWE1 and UBR2 (ubiquitin E3 ligases targeting chromatin-associated proteins). XRN1 and PTBP3 add RNA-processing flavor but the dominant program is chromatin/epigenetic regulation. Neighbor M106's housekeeping character supports these being broadly expressed regulatory programs.
Genes
ACIN1, ASH1L, BDP1, BLTP1, CLTC, EPS15, EXOC2, FAM120B, GATAD2B, GBF1, HUWE1, INPP5D, KAT6A, KDM4C, KIDINS220, KMT2C, MACF1, NIPBL, NUMA1, PARP4, PHC3, PHF3, PTBP3, RABGAP1L, RANBP6, SEC16A, TAF1, UBR2, UGGT1, VPS13C, XRN1, ZBTB40, ZNFX1
Most correlated modules
- Hippo Pathway Signaling · correlation 0.91
- DNA Damage Response · correlation 0.90
- Vesicular Trafficking · correlation 0.89
- mTOR-Exocyst Signaling · correlation 0.88
- ER Antigen Processing · correlation 0.86
- Actin Cytoskeletal Regulation · correlation 0.83
- Metabolic-Translational Coupling · correlation 0.83
- T Cell Identity Program · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.