IFN-gamma Receptor Signaling
Gene co-expression module in Gamma-delta T cells
| Category | Inflammation |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes USP36 (deubiquitinase enriched in nucleolus, regulates Myc stability), EML4 (microtubule-associated, EMAP-like), SLC38A1 (glutamine transporter SNAT1, mTORC1 activation), IFNGR1 (IFN-γ receptor 1, key immune signaling), PGRMC2 (membrane progesterone receptor component, cholesterol/heme metabolism), DHCR7 (7-dehydrocholesterol reductase, cholesterol synthesis), PDE4B (cAMP phosphodiesterase, immune regulation), PLEKHA2 (PH domain, membrane signaling), CCDC93 (retromer complex). IFNGR1 is the clearest immune functional hub. SLC38A1+DHCR7 suggest metabolic reprogramming downstream of IFN-γ signaling. USP36 stabilizes Myc which is downstream of IFN-γ/mTOR. The module is heterogeneous but IFN-γ receptor signaling with metabolic co-regulation is the most coherent interpretation.
Genes
BORCS5, CCDC93, CDC42SE2, DHCR7, EML4, IFNGR1, PDE4B, PGRMC2, PLEKHA2, POFUT2, SLC38A1, USP36
Most correlated modules
- Late Activation Autophagy · correlation 0.84
- Transcription-RNA Coupling · correlation 0.78
- NF-κB Activation · correlation 0.78
- Circadian Clock · correlation 0.77
- TCR Threshold Regulation · correlation 0.77
- Hypoxia Stress Response · correlation 0.76
- cAMP Lipid Signaling · correlation 0.76
- Heat Stress Apoptotic · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.