Heat Stress Apoptotic
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes IER5 (immediate early response gene 5, induced by heat shock and DNA damage, regulates PP2A), DNAJB9 (ERdj4, ER stress/UPR chaperone), AMD1 (AdoMetDC, polyamine synthesis — links to M141/ODC1), PMAIP1 (NOXA, pro-apoptotic BH3-only, p53 target), SOCS3 (JAK-STAT inhibitor, cytokine feedback), DUSP2 (PAC1, activation-induced MAPK phosphatase), NFKBIB (IκBβ, NF-κB inhibitor), PHLDA1 (TDAG51, Akt inhibitor, stress/apoptosis priming), SLC2A3 (GLUT3, stress-induced glucose uptake), YBX3 (cold shock domain, stress-activated RNA regulator). The combination of IER5+DNAJB9+PMAIP1+PHLDA1 defines a heat/proteotoxic stress with apoptotic priming signature. SOCS3+DUSP2+NFKBIB add the concurrent signaling inhibition. This is consistent with stressed/activating gd T cells undergoing proteotoxic stress-induced apoptotic priming.
Genes
AMD1, DBF4, DNAJB9, DUSP2, IER5, NFKBIB, NINJ1, PHLDA1, PMAIP1, RAP2C, SERTAD1, SLC2A3, SOCS3, YBX3
Most correlated modules
- TGF-beta Response · correlation 0.86
- TCR Early Activation · correlation 0.85
- Circadian Clock · correlation 0.85
- Anabolic Activation Response · correlation 0.82
- Late Activation Autophagy · correlation 0.80
- ER Proteotoxic Stress · correlation 0.78
- AP-1 Immediate Early Response · correlation 0.76
- Stress Epigenetic Silencing · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.