Circadian Clock
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes NR1D2 (REV-ERBβ, core circadian clock nuclear receptor), CRY1 (Cryptochrome 1, core circadian clock gene), BHLHE40 (DEC1/SHARP2, circadian-regulated bHLH repressor also induced by hypoxia), MEF2D (MEF2 family TF, T cell survival/differentiation), CDK17 (PctAIRE-related kinase), TSC22D2 (TSC-22 domain, stress/glucocorticoid response), SMAD7 (TGF-β inhibitory SMAD), IRF1 (interferon regulatory factor 1), SLC2A1 (GLUT1, hypoxia/activation metabolism), ITPRIP (IP3R-interacting, calcium signaling). NR1D2+CRY1+BHLHE40 constitute a clear circadian clock module. The additional presence of IRF1, SMAD7, and SLC2A1 may reflect circadian regulation of immune/metabolic genes. This is the most specific signal in the module.
Genes
BHLHE40, CDK17, CPEB2, CRY1, IRF1, ITPRIP, MEF2D, NR1D2, PRKX, RNF125, SLC2A1, SMAD7, TSC22D2, TXNDC11
Most correlated modules
- Late Activation Autophagy · correlation 0.87
- Heat Stress Apoptotic · correlation 0.85
- TGF-beta Response · correlation 0.83
- ER Protein Translocation · correlation 0.79
- IFN-gamma Receptor Signaling · correlation 0.77
- TCR Early Activation · correlation 0.77
- Innate Stress Signaling · correlation 0.74
- T Cell Exhaustion · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.