NF-κB Activation
Gene co-expression module in Gamma-delta T cells
| Category | Inflammation |
|---|---|
| Genes | 22 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 22 genes have a known function matching the annotation |
Why this annotation
The top hub genes are RELB, NFKB1, NFKB2, and NFKBIZ — core NF-κB transcription factors and regulators. Downstream targets include NAMPT, PIM3, KDM6B, NR4A3 (immediate-early activation), ZC3H12A (MCPIP1, mRNA decay), DUSP5 (MAPK feedback), GADD45A (stress/activation), OTULIN (linear deubiquitinase controlling NF-κB), and PPP1R15B (integrated stress response). HERPUD1 links to ER stress. This is a tightly coherent NF-κB-driven T cell activation response module.
Genes
DUSP5, GADD45A, HERPUD1, IL21R, KDM6B, MAFF, NAMPT, NFKB1, NFKB2, NFKBIZ, NR4A3, OTULIN, PER1, PIM3, PPP1R15B, RELB, RNF138, SLC7A5, TAMALIN, TRAF4, ZBTB21, ZC3H12A
Most correlated modules
- Late Activation Autophagy · correlation 0.92
- Chromatin Epigenetic Regulation · correlation 0.88
- ER Proteotoxic Stress · correlation 0.87
- TGF-beta Response · correlation 0.87
- Stress Negative Feedback · correlation 0.84
- hnRNP Splicing Complex · correlation 0.84
- TCR Threshold Regulation · correlation 0.84
- Pre-mRNA Splicing · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.