TGFBR3 — Transforming growth factor beta receptor 3
TGFBR3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TGFBR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ACTN1, AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1 +18 more | View in SCUBA |
| Fibroblasts | TGF-beta Fibroblast Niche ECM production | APCDD1, BAG2, C12orf75, CD55, CES1, CGREF1, COL11A1, CRYAB +8 more | View in SCUBA |
| Gamma-delta T cells | TGF-β Migration Program migration & adhesion | AGTPBP1, AHNAK, CAPN2, CYTH1, FLNA, RAP1GAP2, RASA3, SORL1 +2 more | |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | AGTPBP1, AHNAK, ATP2B4, DIAPH1, FLNA, IQSEC1, ITCH, ITGA4 +8 more | |
| Smooth muscle cells | Notch-TGFbeta Signaling Development | AHI1, CD81, CD9, CPED1, EDIL3, FHL1, GSN, JUND +3 more | View in SCUBA |
About the gene
| Synonyms | betaglycan, BGCAN |
|---|---|
| Chromosome | 1: 91680343-91906335 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
Function
Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta- arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B. In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization. Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity). (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.