PTPN22 — Protein tyrosine phosphatase non-receptor type 22

PTPN22 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PTPN22's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	BCR Signaling Regulation BCR/AP1/NFKb pathway	CBLB, CYTIP, FCRL2, FCRL3, G3BP2, HIVEP1, ITPR2, IVNS1ABP +5 more	View in SCUBA
CD4⁺ T cells	TCR Activation Signaling TCR/AP1/NFKb pathway	AKNA, ATP6V1A, BCL2L11, KIF20B, LAX1, NAA50, NEDD9, NPC1 +6 more	View in SCUBA
CD8⁺ T cells	TCR Proximal Signaling TCR Signaling	ACTN4, CD3G, CMIP, GALNT1, IVNS1ABP, LCP2, MSN, PTPRA +3 more	View in SCUBA
Gamma-delta T cells	NK Receptor Expression cytotoxicity	CRACR2B, GFOD1, GPR171, GPR55, GSTM4, KIR2DL4, KLRC2, KLRC3 +4 more
Innate lymphoid cells	RNA Chromatin Regulation RNA processing & translation	BTBD7, CCDC59, CWC25, DDX3Y, DNTTIP2, HNRNPU, KRR1, MRFAP1 +5 more	View in SCUBA
Macrophages	Myeloid Differentiation Identity Developmental	ADCK2, ALOX5, ATP2C1, CCDC6, CDK6, CMTM7, DEF6, EEF2K +21 more	View in SCUBA
Mucosal-associated invariant T cell	TCR Signal Attenuation Immune regulation	AFF4, BORCS5, CENPC, CHD2, CRACR2A, CRYBG1, DUSP16, FAS +8 more
Natural Killer cells	NK Immune Checkpoint Immune regulation	AKAP13, CHD1, G3BP2, LIMS1, MORF4L2, P2RY10, RANBP2, SAMSN1 +1 more	View in SCUBA
Neutrophils	Endocytic Vesicular Trafficking Vesicular traficking	CLINT1, DNAJC13, LNPK, PHACTR2, PRAM1, PRKAA1, SEC63, VCL

About the gene

Synonyms	Lyp, Lyp1, Lyp2, PTPN8
Chromosome	1: 113813811-113871753
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Hydrolase, Protein phosphatase
Biological process	Autophagy, Immunity, Lipid metabolism

Function

Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy. Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3. Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.