Hypoxia Tissue Adaptation
Gene co-expression module in Gamma-delta T cells
| Category | Tissue residence |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
EPAS1 (HIF-2α) is a master hypoxia/tissue-adaptation transcription factor. ABCB1 (MDR1/P-glycoprotein) is a canonical marker of tissue-resident memory T cells and efflux pump under hypoxia. SPRY1 suppresses RTK signaling during adaptation. CCRL2 is an atypical chemokine receptor expressed in tissue-resident cells. SAMSN1 modulates immune activation. STAM and SNX9 regulate endosomal trafficking. Neighbor context with M49 (gut tissue residence) reinforces a tissue-adaptation/hypoxia program, possibly in a tissue-resident gd T cell subset.
Genes
ABCB1, ADAMTS17, ANKRD28, CCRL2, EPAS1, FAM3C, KLHL6, LDLRAD4, PHTF1, PLPP1, PRKAR2B, RHOQ, RNF122, SAMSN1, SMIM3, SNX9, SPRY1, STAM, TARS3
Most correlated modules
- AHR/NF-κB Survival · correlation 0.94
- Tissue Resident CD103+ · correlation 0.91
- Activation Stress Response · correlation 0.90
- NK Receptor Expression · correlation 0.89
- Gut-homing Residence · correlation 0.88
- IRF4 T-cell Activation · correlation 0.84
- T Cell Exhaustion · correlation 0.84
- mRNA Splicing Regulation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.