mRNA Splicing Regulation
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 27 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 27 genes have a known function matching the annotation |
Why this annotation
The most numerous and connected genes are RNA-binding proteins involved in splicing and mRNA processing: TRA2A, TRA2B (SR splicing factors), HNRNPL (hnRNP splicing regulator), CELF2 (RNA-binding splicing factor), RBM8A (exon junction complex). ELF1 is an ETS transcription factor regulating lymphocyte gene expression. MALT1 and RIPK2 participate in NF-κB/CBM signaling downstream of TCR/BCR. CUL3 is a ubiquitin E3 ligase. KCTD9 activates NK cells. HECA regulates lymphocyte homing. The module mixes RNA processing/splicing with NF-κB immune signaling, but RNA-binding proteins dominate by number. The broad expression (40.3% positive, highest mean expression in batch) supports a housekeeping/post-transcriptional regulation role.
Genes
ARF6, BTG3, CAPN7, CDV3, CELF2, CNBD2, CUL3, CYTIP, ELF1, HECA, HNRNPL, KAT6B, KCTD9, MALT1, PNPLA2, PREPL, RASA2, RBM8A, RIPK2, SCAND1, SERTAD2, SF3B5, SRGN, TRA2A, TRA2B, WTAP, ZNF721
Most correlated modules
- Activation Stress Response · correlation 0.92
- Chromatin Remodeling Signaling · correlation 0.90
- TCR Inhibitory Signaling · correlation 0.87
- NK Receptor Expression · correlation 0.86
- Chromatin Repression · correlation 0.84
- Autophagy Stress Response · correlation 0.83
- Ubiquitin-p53 Regulation · correlation 0.83
- AHR/NF-κB Survival · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.