T Cell Development
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes PAG1, SATB1, PLCB1, MICAL2, LRIG1, SVIL, and ANK3 collectively point to a chromatin/transcriptional regulation and cytoskeletal organization program in T cells. SATB1 is the master chromatin organizer critical for thymocyte maturation and T cell gene regulation. PAG1 (Cbp) is a lipid raft-associated phosphoprotein that regulates TCR signaling threshold and is important in T cell development. PLCB1 mediates calcium signaling. LRIG1 is a stem cell marker associated with tissue-resident and memory cell maintenance. MICAL2 and SVIL are actin remodeling proteins. ERN1 (IRE1α) is an ER stress sensor. ATF7IP2 is a chromatin-associated protein. This module best reflects a T cell developmental/maturation program combining chromatin remodeling (SATB1), signaling threshold control (PAG1), and cytoskeletal organization, consistent with thymic or early peripheral maturation of gd T cells.
Genes
ANK3, ATF7IP2, CERK, ERN1, FKBP11, LRIG1, MICAL2, PAG1, PBXIP1, PHACTR2, PLCB1, SATB1, SVIL
Most correlated modules
- Naïve T Cell State · correlation 0.83
- Naive T cell quiescence · correlation 0.78
- Death Receptor Apoptosis · correlation 0.74
- Lymphocyte Tissue Egress · correlation 0.73
- gd T Cell Identity · correlation 0.68
- γδT17 Effector · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.