Ubiquitin-Proteasome Trafficking
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include NUP42 (nucleoporin/nuclear pore), FBXL6 (F-box/ubiquitin E3 ligase), ZFAND2B (ubiquitin-like zinc finger stress response), RNF187 (RING-domain E3 ubiquitin ligase), VPS29 (retromer vesicle sorting), TCIRG1 (vacuolar ATPase subunit a3), MTG1 (mitochondrial GTPase ribosome assembly). Module is moderate coherence with mixed ubiquitin-proteasome, vesicular/endosomal trafficking, and nuclear pore components. Neighbor context with M108 (metabolic housekeeping) and M99 suggests these are constitutive cellular maintenance programs. The ubiquitin ligase theme (FBXL6, RNF187, ZFAND2B) is most prominent.
Genes
ARHGEF9, DDX50, DENND10, FBXL6, LIMK1, MTG1, NUP42, PEX2, RNF187, SERPINB6, SKAP2, SMIM7, TCIRG1, TP53I13, VPS29, ZFAND2B, ZNF37A
Most correlated modules
- DNA Damage Repair · correlation 0.86
- mRNA Splicing Regulation · correlation 0.85
- Metabolic Housekeeping · correlation 0.85
- Pre-mRNA Splicing · correlation 0.84
- Actin-based Motility · correlation 0.80
- Interferon Stimulated Response · correlation 0.77
- Transcriptional Repressor Complex · correlation 0.75
- Chromatin TF Regulation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.