SKAP2 — Src kinase associated phosphoprotein 2
SKAP2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SKAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Actin cytoskeleton remodeling Cytoskeletal | ACTR2, BASP1, CAPZA1, CDV3, EIF3A, FAM107B, GRB2, HCLS1 +9 more | View in SCUBA |
| Gamma-delta T cells | Ubiquitin-Proteasome Trafficking Protein processing & ER | ARHGEF9, DDX50, DENND10, FBXL6, LIMK1, MTG1, NUP42, PEX2 +8 more | |
| Innate lymphoid cells | Pyruvate Metabolism Metabolism | ABCB1, ADI1, ARID1B, ATF7IP2, CFAP298, EIF2AK2, HNRNPH3, MINDY2 +10 more | View in SCUBA |
| Lymphatic endothelial | Endosomal Vesicle Trafficking Housekeeping | ADAM10, APC, APP, ATP9A, GLG1, MTR, NCOA3, PCNX4 +5 more | View in SCUBA |
| Macrophages | Myeloid Innate Signaling Innate immunity | ADCY7, ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC +34 more | View in SCUBA |
| Pericytes | RAS-Chromatin Signaling Housekeeping | CD2AP, CNOT6L, EFCAB14, SMARCA2, SOS1, TMTC1, WNK1 | View in SCUBA |
About the gene
| Synonyms | RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R |
|---|---|
| Chromosome | 7: 26667068-26995239 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | B-cell activation |
Function
May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.