DNA Damage Repair
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 24 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 24 genes have a known function matching the annotation |
Why this annotation
Top hub gene XPC is a key DNA damage recognition factor in nucleotide excision repair (NER). ASF1A is a histone chaperone critical for DNA replication and repair chromatin dynamics. DDX18 is an RNA helicase involved in ribosome biogenesis. PPWD1 is a peptidylprolyl isomerase with pre-mRNA splicing roles. UFL1 is an E3 ligase for UFMylation linked to DNA damage response and ER stress. KLRD1 (CD94) is a gd_T/NK cell marker with moderate membership. The DNA repair program (XPC, ASF1A) is the most specific signal among hub genes, with a background of general RNA/protein processing.
Genes
ANKRD10, ASF1A, DDX18, DNAJC17, ENPP5, KLRC4, KLRD1, NARS1, NDUFV3, NIT2, OXLD1, PPCS, PPM1K, PPWD1, RINL, TBRG1, TMEM165, TMEM80, TRABD, UBXN4, UFL1, UFSP2, XPC, ZNF414
Most correlated modules
- mRNA Splicing Regulation · correlation 0.86
- Ubiquitin-Proteasome Trafficking · correlation 0.86
- SR Kinase & RNA · correlation 0.84
- Metabolic Housekeeping · correlation 0.83
- Actin-based Motility · correlation 0.79
- Chromatin Epigenetic Regulation · correlation 0.79
- Chromatin TF Regulation · correlation 0.77
- RNA Splicing Nuclear · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.