TCIRG1 — T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
TCIRG1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TCIRG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA splicing RNA processing | ANKRD11, ARGLU1, CYBC1, LUC7L3, PLCG2, PNN, SON, SRRM2 +1 more | View in SCUBA |
| CD4⁺ T cells | Leukocyte Motility migration & adhesion | ATP2A3, HSH2D, LRP12, LZTFL1, MYO1G, MYO9B, NBEAL2, PPARG +1 more | View in SCUBA |
| Gamma-delta T cells | Ubiquitin-Proteasome Trafficking Protein processing & ER | ARHGEF9, DDX50, DENND10, FBXL6, LIMK1, MTG1, NUP42, PEX2 +8 more | |
| Innate lymphoid cells | NK Receptor Signaling Cytotoxicity | B2M, CD48, CLEC2B, DCK, FCER1G, FKBP11, GPR108, HLA-A +12 more | View in SCUBA |
| Macrophages | Phagocytic Endolysosomal Lysosomal & pahgocytosis | ABHD2, ACTN4, AP3S1, ARF6, ATP6V1B2, CD151, CERS2, CNIH1 +27 more | View in SCUBA |
| Monocytes | Inflammatory Monocyte Activation Inflammatory | ALDOA, C11orf98, CLEC2B, CNIH4, CRIP1, GRINA, IFITM2, LEPROTL1 +5 more | View in SCUBA |
About the gene
| Synonyms | a3, Atp6i, ATP6N1C, ATP6V0A3, OC-116, OC116, TIRC7 |
|---|---|
| Chromosome | 11: 68039025-68050895 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Hydrogen ion transport, Ion transport, Transport |
Function
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Seems to be directly involved in T-cell activation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.