VPS29 — VPS29 retromer complex component
VPS29 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VPS29's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Mitochondrial OxPhos Mitochondrial & OxPhos | ATP5PF, COX6A1, COX6C, GSTP1, MGST3, NDUFA12, NDUFA8, NDUFB10 +6 more | View in SCUBA |
| Gamma-delta T cells | Ubiquitin-Proteasome Trafficking Protein processing & ER | ARHGEF9, DDX50, DENND10, FBXL6, LIMK1, MTG1, NUP42, PEX2 +8 more | |
| Goblet cells | Spliceosome Assembly RNA processing & translation | ALYREF, ANAPC11, BANF1, LSM4, MRPL51, PPIH, PTBP1, RAN +8 more | View in SCUBA |
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, HAX1, IL27RA +16 more | View in SCUBA |
| Macrophages | Spliceosomal snRNP Cell cycle | ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, FKBP3, GLRX5 +30 more | View in SCUBA |
About the gene
| Synonyms | DC15, DC7, PEP11 |
|---|---|
| Chromosome | 12: 110491083-110502111 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Host-virus interaction, Protein transport, Transport |
Function
Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27- retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27. (Microbial infection) The heterotrimeric retromer cargo- selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.