mRNA Decay Trafficking
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
HPS3 (Hermansky-Pudlak syndrome protein 3) functions in lysosome-related organelle biogenesis. SPG11 mediates endolysosomal membrane trafficking. DCP2 is an mRNA decapping enzyme central to mRNA decay, and TIAL1 is an RNA-binding protein involved in mRNA decay and stress granule assembly. IRAK4 is a kinase in TLR/IL-1R innate immune signaling. XPO7 handles nuclear export of specific cargoes. CHAMP1 and LIN52 participate in cell cycle/chromosome biology. The module has moderate coherence reflecting a mixed program; the DCP2/TIAL1 axis and vesicle trafficking (HPS3/SPG11) are the most coherent sub-themes, pointing toward post-transcriptional mRNA regulation and lysosomal trafficking.
Genes
CEP290, CHAMP1, DCP2, GTF2I, HPS3, IRAK4, IWS1, LIN52, MYO9A, SPG11, TIAL1, XPO7, ZNF641
Most correlated modules
- Rho GTPase Signaling · correlation 0.83
- mRNA Splicing Regulation · correlation 0.82
- Actin Cytoskeletal Regulation · correlation 0.80
- Ubiquitin Protein Quality · correlation 0.78
- Interferon Antiviral Response · correlation 0.78
- Interferon Stimulated Response · correlation 0.78
- Chromatin TF Regulation · correlation 0.77
- Chromatin Architecture · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.