GTF2I — General transcription factor IIi

GTF2I belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GTF2I's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Membrane trafficking Housekeeping	BCL2, CLSTN1, GLB1, HPSE, HSDL2, LENG8, MBIP, MCF2L2 +19 more	View in SCUBA
Gamma-delta T cells	mRNA Decay Trafficking RNA processing & translation	CEP290, CHAMP1, DCP2, HPS3, IRAK4, IWS1, LIN52, MYO9A +4 more
Glial cells	Glial RNA Homeostasis RNA processing & translation	ATRX, DYNC1H1, NCL, RBM25, SCN9A, SRSF11, SYNM	View in SCUBA
Goblet cells	Chromatin Remodeling chromatin regulation & transcription	BAZ2B, BPTF, INSR, MYO10, PDZD8, RERE, TOP2B, ZKSCAN1	View in SCUBA
Innate lymphoid cells	Transcriptional Regulation DNA regulation & transcription	ACAA1, ATRX, C1orf43, CARHSP1, CHTOP, CTDSP1, CTR9, DRAP1 +18 more	View in SCUBA
Macrophages	Hypoxia-driven Activation Inflammatory	ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more	View in SCUBA
Pericytes	ER-Actin Cytoskeletal Cytoskeletal	A2M, CSDE1, IQGAP1, KTN1, MAP4K4, SEC62, SERINC1, WASF2	View in SCUBA

About the gene

Synonyms	BAP-135, BTKAP1, DIWS, IB291, SPIN, TFII-I, WBSCR6
Chromosome	7: 74650231-74760692
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA- binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.