Interferon Antiviral Response
Gene co-expression module in Gamma-delta T cells
| Category | Inflammation |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 23 genes have a known function matching the annotation |
Why this annotation
Top hub SLFN5 is a well-characterized interferon-stimulated gene (ISG) with antiviral and immune modulatory functions. DDX17 and DDX60L are RNA helicases with ISG/antiviral roles. RESF1 is involved in retrotransposon silencing (innate defense). PIK3CD is the lymphocyte-specific PI3K delta critical for TCR/BCR signaling. RAD50 links to DNA damage sensing. SENP7 (SUMO-targeted ubiquitin regulation) and ZKSCAN1 (zinc finger) are supporting members. The module's strong coherence and ISG-dominant hubs support an interferon/antiviral innate immune program in gd T cells.
Genes
ANKRD44, DDX17, DDX60L, IARS2, KIAA0319L, KRBOX5, LZIC, MIA2, PIK3CD, PRR14L, RAD50, RCSD1, RESF1, RNF34, SENP7, SLC25A45, SLC25A46, SLFN5, VPS36, ZFP90, ZKSCAN1, ZNF302, ZNF638
Most correlated modules
- Actin Cytoskeletal Regulation · correlation 0.85
- Immune Negative Regulation · correlation 0.84
- Ubiquitin Protein Quality · correlation 0.83
- Chromatin TF Regulation · correlation 0.81
- T cell Survival · correlation 0.81
- mTOR-Exocyst Signaling · correlation 0.79
- Rho GTPase Signaling · correlation 0.79
- mRNA Decay Trafficking · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.