SPG11 — SPG11 vesicle trafficking associated, spatacsin
SPG11 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPG11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Decay Trafficking RNA processing & translation | CEP290, CHAMP1, DCP2, GTF2I, HPS3, IRAK4, IWS1, LIN52 +4 more | |
| Macrophages | Sphingolipid Membrane Homeostasis Lipid metabolism | ACER3, AGPAT3, ARHGEF11, ATP2A2, C9orf72, CMIP, DMXL2, DOCK8 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | Histone Modification DNA/chromatin regulation | ANKRD17, ARHGEF6, ASH1L, CLTC, FAM120B, KDM4C, NRDC, PCM1 +3 more |
About the gene
| Synonyms | ALS5, FLJ21439, KIAA1840 |
|---|---|
| Chromosome | 15: 44554818-44663688 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
Function
May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.