LGR6 — Leucine rich repeat containing G protein-coupled receptor 6
LGR6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LGR6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Terminal T Differentiation T cell maturation | AXIN1, B3GAT1, C1orf174, CEBPA, ENC1, F2R, GLUL, GTF3C1 +10 more | |
| Natural Killer cells | Cytotoxic NK Maturation Cytotoxicity | ADGRG1, AKR1C3, CXCR2, FCGR3A, FGFBP2, GK5, MTSS1, PRF1 +4 more | View in SCUBA |
| Smooth muscle cells | Oxidative Muscle Metabolism Mitochondrial & OxPhos | CAV2, COX7A1, CRIP2, FXYD1, HCFC1R1, MFGE8, MGST3, NDUFB7 +2 more | View in SCUBA |
About the gene
| Synonyms | FLJ14471 |
|---|---|
| Chromosome | 1: 202193799-202319781 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Wnt signaling pathway |
Function
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.