GNPTAB — N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
GNPTAB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNPTAB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Cytotoxic Gut Effector cytotoxicity | ATP8B4, CCND2, CD63, CEBPB, CSF1, CTSA, GNLY, GZMA +3 more | View in SCUBA |
| Gamma-delta T cells | Lysosomal Biogenesis Protein processing & ER | ABI3, APLP2, ATP10A, B3GALT4, BAX, CD63, CTNNA1, DOCK5 +14 more | |
| Natural Killer cells | NK Cytotoxic Activation Cytotoxicity | ABI3, ALOX5AP, ARHGDIB, BPGM, CD247, GZMA, HCLS1, LAT2 +3 more | View in SCUBA |
About the gene
| Synonyms | GNPTA, KIAA1208, MGC4170 |
|---|---|
| Chromosome | 12: 101745499-101830959 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Transferase |
Function
Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.