Post-transcriptional RNA Regulation
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Small strong-coherence module. Hub genes: FUBP1 (Far Upstream Element Binding Protein 1 — regulates MYC transcription and mRNA stability), IPO7 (importin-7, nuclear import of H1 histones and ribosomal proteins — nuclear transport), OSBPL3 (oxysterol-binding protein-like 3, lipid transfer/Ras signaling), DHX15 (DEAH helicase, spliceosome disassembly), HNRNPA3 (heterogeneous nuclear ribonucleoprotein, RNA processing/export), PLEKHB2 (pleckstrin homology domain, lipid binding), SP140 (nuclear body component, lymphocyte-specific — immune gene regulation), ITPR2 (inositol trisphosphate receptor type 2, Ca2+ release from ER), CCNG1 (cyclin G1, p53 target, cell cycle regulation). SP140 is a lymphocyte-specific chromatin/nuclear body regulator important for immune gene silencing. FUBP1 and HNRNPA3 drive post-transcriptional regulation. The module likely represents post-transcriptional RNA regulation in lymphocytes, co-expressed with SP140-mediated chromatin regulation. Neighbor context: RNA processing theme connects to M71 (SRSF4, CPSF3) and M173 (SF3B1, DDX23).
Genes
CCNG1, DHX15, FUBP1, HNRNPA3, IPO7, ITPR2, OSBPL3, PLEKHB2, SP140
Most correlated modules
- Metabolic-Translational Coupling · correlation 0.86
- DNA Damage Response · correlation 0.83
- Spliceosome Regulation · correlation 0.83
- Chromatin Remodeling · correlation 0.82
- Hippo Pathway Signaling · correlation 0.78
- NK/T Cell Identity · correlation 0.78
- Wnt-STAT3 Signaling · correlation 0.77
- Actin Cytoskeletal Regulation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.