TCERG1 — Transcription elongation regulator 1
TCERG1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TCERG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Spliceosome Regulation RNA processing & translation | AFF1, ATOSA, CEP95, CSNK1A1, FAM13B, KANSL3, KIF5B, MYSM1 +15 more | |
| Macrophages | RNA Processing Housekeeping Housekeeping | BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L +32 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin & Splicing DNA/chromatin regulation | ACIN1, ADAR, API5, BAZ2A, CDC73, CDK12, COPA, FUBP1 +11 more |
About the gene
| Synonyms | CA150, TAF2S, Urn1 |
|---|---|
| Chromosome | 5: 146447311-146511961 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Activator, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.