IFN-gamma Effector Program
Gene co-expression module in Glial cells
| Category | Inflammation |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes: TAP1 (antigen peptide transporter, IFN-gamma target), LAP3 (leucine aminopeptidase), APOL2 and APOL1 (apolipoprotein L, IFN-inducible, innate immunity), IL32 (pro-inflammatory cytokine, IFN-related), IL18BP (IL-18 binding protein, anti-inflammatory feedback), PLSCR1 (phospholipid scramblase, IFN-inducible), TNFSF13B (BAFF, B-cell survival factor), IDO1 (indoleamine 2,3-dioxygenase, IFN-gamma target, immune suppression), TYMP (thymidine phosphorylase, angiogenesis/IFN-inducible), GBP1 (guanylate-binding protein, IFN-inducible), IFI44L (IFN-induced), ODF3B, PPA1. This is the highest inflammation delta module in the batch (UC: 2.312), and nearly all genes are canonical IFN-gamma effectors with a strong IDO1/immune regulation signature. TAP1 links to antigen processing (connecting to M73/M2), while IDO1, IL18BP, and TNFSF13B indicate downstream immunomodulatory effector functions. This module represents advanced IFN-gamma-driven immune activation including tryptophan catabolism and innate defense.
Genes
APOL1, APOL2, GBP1, IDO1, IFI44L, IL18BP, IL32, LAP3, ODF3B, PLSCR1, PPA1, TAP1, TNFSF13B, TYMP
Most correlated modules
- Type I/II Interferon Response · correlation 0.94
- NF-κB/IFN Inflammatory · correlation 0.86
- Inflammatory Cytokine Signaling · correlation 0.78
- MHC-II Antigen Presentation · correlation 0.77
- MHC-I Antigen Presentation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.