TNFSF13B — TNF superfamily member 13b
TNFSF13B belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFSF13B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, AUTS2, COLQ, DSE, ERN1, GPR65, IFI44 +12 more | View in SCUBA |
| Fibroblasts | Subepithelial Fibroblast Identity Developmental | ANGPTL1, APBB1IP, ARHGAP15, CNTN1, CP, ECM2, EFEMP1, FAM107A +12 more | View in SCUBA |
| Glial cells | IFN-gamma Effector Program Inflammation | APOL1, APOL2, GBP1, IDO1, IFI44L, IL18BP, IL32, LAP3 +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Granulocyte Commitment Granulocyte development | C16orf74, C1QTNF4, CEACAM4, CEBPA, CLEC11A, CPVL, CSF3R, IGFBP2 +6 more | |
| Innate lymphoid cells | Innate Inflammatory Activation Inflammation | ARL6IP5, BST2, CD2, CD63, FTL, HMGB1, ITM2B, MGST3 +7 more | View in SCUBA |
| Macrophages | Immunoproteasome Induction Inflammatory | CBR1, DAPP1, DYNLT1, EPSTI1, IFI35, LAP3, LGALS9, LYSMD2 +12 more | View in SCUBA |
| Neutrophils | IFN-gamma Response Antiviral | CARD16, CCR1, FFAR2, GBP1, GBP5, IFIT2, IFIT3, IFITM3 +4 more |
About the gene
| Synonyms | BAFF, BLYS, CD257, TALL-1, TALL1, THANK, TNFSF20 |
|---|---|
| Chromosome | 13: 108251240-108308484 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Immunity |
Function
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T- cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B- cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma- stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.