IL18BP — Interleukin 18 binding protein
IL18BP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL18BP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IFN-gamma Response Inflammation | APOL2, APOL6, BATF2, CARD16, CASP1, CD40, CXCL10, CXCL11 +18 more | View in SCUBA |
| Glial cells | IFN-gamma Effector Program Inflammation | APOL1, APOL2, GBP1, IDO1, IFI44L, IL32, LAP3, ODF3B +5 more | View in SCUBA |
About the gene
| Synonyms | IL18BPa |
|---|---|
| Chromosome | 11: 71998613-72007315 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
Function
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.