SPATA13 — Spermatogenesis associated 13
SPATA13 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPATA13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Endothelial cell development | AMD1, AQP7, ARMH4, CDC14B, FBXO34, GATA2, GLUL, KLF3 +7 more | View in SCUBA |
| Gamma-delta T cells | RNA Splicing Processing RNA processing & translation | ABCF2, ACTR1B, ARF3, C1orf35, CDK11B, DCAF8, DDX39B, EIF4EBP2 +16 more | |
| Glial cells | Actin Remodeling Migration migration & adhesion | CALD1, CAST, CD46, GLIPR2, GSTK1, KTN1, TCEAL4 | View in SCUBA |
| Monocytes | NLRP3 Inflammasome Activation Innate immunity | ACSL1, BASP1, CCDC71L, CCL20, EREG, F3, FAM107B, LRG1 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Transcriptional Identity T cell maturation | AAK1, ANKRD36B, ATG16L2, BCL11B, EMB, ETS1, GOLGA8B, HNRNPUL2 +8 more |
About the gene
| Synonyms | ARHGEF29, ASEF2, FLJ31208 |
|---|---|
| Chromosome | 13: 23979805-24307074 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.