SCUBA

CAST — Calpastatin

CAST belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CAST's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsMembrane adhesion remodeling
migration & adhesion
ARL6IP5, ATP6V0E1, CAMK1D, CELF2, DDAH2, EMP3, FLNA, FXYD5 +6 moreView in SCUBA
CD4⁺ T cellsInflammatory effector
Immune regulation
C3AR1, CLDND1, CMTM3, CREB3L2, EIF4E3, EPB41, FYCO1, IL18R1 +9 moreView in SCUBA
EnterocytesActin cytoskeleton
Cytoskeletal
ACTB, ACTG1, CDC42EP5, CLDN7, JPT1, MYL12B, PIGR, TMEM54View in SCUBA
FibroblastsECM Homeostasis
ECM remodeling
CAVIN3, FAM114A1, HCFC1R1, MXRA7, PPIC, SELENOW, TIMP2, TUBBView in SCUBA
Glial cellsActin Remodeling Migration
migration & adhesion
CALD1, CD46, GLIPR2, GSTK1, KTN1, SPATA13, TCEAL4View in SCUBA
Innate lymphoid cellsNK Homing Circulating
Homing & TEM
ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CDKN2D +37 moreView in SCUBA
Natural Killer cellsNK Cell Maturation
Differentiation
GNG2, GZMB, HIPK2, PPP2R5C, PRKCH, STK10, SYNE2, ZEB2View in SCUBA
Smooth muscle cellsNon-muscle Actomyosin
Cytoskeletal
C1R, CD63, CLIC1, DYNLL1, FILIP1L, LDHA, LIMS1, MYH9 +4 moreView in SCUBA

About the gene

Chromosome5: 96525267-96779595
Predicted locationIntracellular
Essential geneNo
Protein classCancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular functionProtease inhibitor, Thiol protease inhibitor

Function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.