SCUBA

YWHAQ — Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta

YWHAQ belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

YWHAQ's module in each cell type

Cell typeModuleShares the module with
CD8⁺ T cellsGlycolysis Program
Housekeeping
ADRM1, CSNK2B, ENO1, MTHFD2, NUTF2, P4HB, PGAM1, PKM +6 moreView in SCUBA
EndothelialSpliceosome snRNP Assembly
RNA processing & translation
BAX, CBX3, CCT2, CCT4, EIF3I, FGFR1, HNRNPAB, HNRNPC +6 moreView in SCUBA
Glial cellsActin Cytoskeletal Organization
Cytoskeletal
ACTB, ACTG1, CALM1, CFL1, CIRBP, DYNLL1, ELOC, MORF4L2 +1 moreView in SCUBA
Goblet cellsChromatin RNA Regulation
chromatin regulation & transcription
ANP32A, CBX1, HDAC2, HNRNPA0, HNRNPM, KHDRBS1, NONO, RBMX +1 moreView in SCUBA
Innate lymphoid cellsRNA-binding & Splicing
RNA processing & translation
CALM1, DYNLL1, FUS, HNRNPA2B1, HNRNPAB, NCL, NUDC, PPIG +4 moreView in SCUBA
MacrophagesUbiquitin-Proteasome System
Housekeeping
ACTR10, ADSS2, ATXN10, CAND1, CYRIB, DKC1, DPM1, EIF4E +18 moreView in SCUBA
Mucosal-associated invariant T cellAnti-inflammatory Homing
Tissue residence
ANXA1, GPR183, NASP, PNP, TAGLN2, TUBA1C, UBE2A, VIM
Smooth muscle cellsOxPhos & proteasome
Mitochondrial & OxPhos
CD151, CHCHD2, COX5B, EID1, NDUFA11, NDUFB2, NDUFB9, NEDD8 +8 moreView in SCUBA

About the gene

Synonyms14-3-3, HS1
Chromosome2: 9583967-9630997
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins, Transporters

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.