Collagen ECM Deposition
Gene co-expression module in Glial cells
| Category | ECM remodeling |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes are predominantly collagens (COL5A2, COL4A1, COL1A1, COL15A1, COL18A1, COL4A2, COL28A1, COL6A2) spanning basement membrane and fibrillar types, with integrin receptors ITGB1/ITGA1 mediating cell-matrix signaling and FLNA linking ECM to actin cytoskeleton. Core coherence and uniform expression confirm a tightly regulated ECM deposition program expressed across glial subsets, consistent with enteric glia contributing to the intestinal basement membrane.
Genes
COL15A1, COL18A1, COL1A1, COL28A1, COL4A1, COL4A2, COL5A2, COL6A2, FLNA, ITGA1, ITGB1
Most correlated modules
- Enteric Glial Identity · correlation 0.85
- Glial Adhesion Identity · correlation 0.85
- Glial Neural Scaffolding · correlation 0.85
- Glial ECM Scaffold · correlation 0.80
- Peripheral Glial Myelination · correlation 0.78
- Glial Homeostatic Identity · correlation 0.75
- TGF-beta ECM Remodeling · correlation 0.74
- TGF-beta Response · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.