SPCS1 — Signal peptidase complex subunit 1
SPCS1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPCS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Oxidative Phosphorylation Mitochondrial & OxPhos | AP2S1, ATP5F1C, ATP5PF, COPS9, COX6B1, EID1, FAM89B, FDPS +19 more | View in SCUBA |
| Fibroblasts | ER Secretory Processing Housekeeping | DAD1, ELOB, FKBP1A, MYL12B, POLR2L, PPIB, RABAC1, SSR4 +2 more | View in SCUBA |
| Gamma-delta T cells | Translation Initiation RNA processing & translation | BTF3, C12orf57, COMMD6, COX4I1, COX7C, EEF1B2, EEF1D, EEF1G +18 more | |
| Goblet cells | ER Protein Processing Protein processing & ER | ALG5, ARPC1A, ARPC3, COPZ1, DAD1, DYNLT1, POMP, PSMA5 | View in SCUBA |
| Innate lymphoid cells | RNA Splicing Processing RNA processing & translation | ATP5F1C, CHMP2A, CHMP4A, CYBA, DSTN, DYNC1I2, DYNLRB1, FKBP3 +16 more | View in SCUBA |
| Macrophages | ER Protein Processing Housekeeping | ACTR1A, ANXA7, ATP6AP1, ATP6AP2, ATP6V0B, ATP6V0E1, AUP1, BCAP31 +41 more | View in SCUBA |
| Smooth muscle cells | OxPhos & proteasome Mitochondrial & OxPhos | CD151, CHCHD2, COX5B, EID1, NDUFA11, NDUFB2, NDUFB9, NEDD8 +8 more | View in SCUBA |
About the gene
| Synonyms | HSPC033, SPC1, SPC12, YJR010C-A |
|---|---|
| Chromosome | 3: 52704955-52711148 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins |
Function
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity (By similarity). (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV). Plays a key role in the post- translational processing of flaviviral structural proteins prM, E, and NS1. In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.