DAD1 — Defender against cell death 1
DAD1 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DAD1's module in each cell type
About the gene
| Synonyms | OST2 |
|---|---|
| Chromosome | 14: 22564907-22589224 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Apoptosis |
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N- glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B- containing OST complexes. Loss of the DAD1 protein triggers apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.