Mitochondrial Chaperone
Gene co-expression module in Goblet cells
| Category | Protein processing & ER |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
HSPD1 and HSPE1 are the mitochondrial chaperonin HSP60/HSP10 complex, involved in protein folding under stress and baseline housekeeping. C1QBP is a multifunctional mitochondrial matrix protein that binds HSP60. PA2G4 (EBP1) and CACYBP are involved in protein complex assembly and ubiquitin-related processes. LSM2 connects to the RNA processing neighborhood (M22). ANP32B and DEK are chromatin-associated. LDHB is a metabolic enzyme. The dominant signal is mitochondrial chaperone/protein quality control, co-expressed with RNA processing neighbors, suggesting a coupled housekeeping/proteostasis program. Significantly downregulated in inflammation and restored in remission supports a constitutive housekeeping program suppressed during inflammatory stress.
Genes
ANP32B, C1QBP, CACYBP, DEK, HSPD1, HSPE1, LDHB, LSM2, PA2G4
Most correlated modules
- Spliceosome Assembly · correlation 0.86
- Chromatin Remodeling Repair · correlation 0.84
- SR Splicing Factors · correlation 0.79
- hnRNP RNA Processing · correlation 0.77
- MCM Replication Licensing · correlation 0.73
- CCT Chaperonin Complex · correlation 0.73
- Replication Fork Checkpoint · correlation 0.72
- S/G2 Preparation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.