MCM Replication Licensing
Gene co-expression module in Goblet cells
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
MCM3, MCM4, MCM5, MCM6, MCM7 (MCM2-7 helicase complex, replication licensing/unwinding), PCNA (sliding clamp), GINS2 (CMG helicase component), HELLS (chromatin remodeling helicase at replication forks), DNMT1 (maintenance methylation during replication), FAM111B (replication fork associated), CDT1 (replication licensing factor), DUT (dUTPase, replication fidelity), NASP (histone chaperone, replication). This is the most canonical DNA replication initiation and elongation module, dominated by the MCM complex and CMG helicase. Coherence is core, low expression/pct positive consistent with cycling minority. Part of the same cell-cycle neighborhood as M49 and M51.
Genes
CDT1, DNMT1, DUT, FAM111B, GINS2, HELLS, MCM3, MCM4, MCM5, MCM6, MCM7, NASP, PCNA
Most correlated modules
- S-phase DNA Replication · correlation 0.88
- Replication Fork Checkpoint · correlation 0.87
- Chromatin Remodeling Repair · correlation 0.82
- Mitochondrial Chaperone · correlation 0.73
- FOXM1-driven G2/M · correlation 0.58
- Mitochondrial Biogenesis · correlation 0.57
- Pyroptosis Stress Response · correlation 0.53
- Mitochondrial Biogenesis · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.