Replication Fork Checkpoint
Gene co-expression module in Goblet cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
LIG1 (DNA ligase I, replication/repair), FANCI (Fanconi anemia pathway, replication stress), PKMYT1 (G2/M kinase), ATAD2 (chromatin remodeler active in S/G2), CLSPN (replication checkpoint, Claspin), BRCA2 (DNA repair/replication fork protection), RRM1 (ribonucleotide reductase, dNTP synthesis), CENPM (kinetochore, mitosis), DNAJC9 (histone chaperone at replication forks). This is a tight DNA replication/replication stress checkpoint module, overlapping with M49 and M80 in the same cell-cycle neighborhood. The G2/M kinase PKMYT1 and CENPM add a late S/G2 flavor.
Genes
ATAD2, BRCA2, CENPM, CLSPN, DNAJC9, FANCI, LIG1, PKMYT1, RRM1
Most correlated modules
- S-phase DNA Replication · correlation 0.95
- MCM Replication Licensing · correlation 0.87
- Chromatin Remodeling Repair · correlation 0.84
- FOXM1-driven G2/M · correlation 0.83
- Spliceosome Assembly · correlation 0.72
- Mitochondrial Chaperone · correlation 0.72
- S/G2 Preparation · correlation 0.71
- Pyroptosis Stress Response · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.