Chromatin Remodeling Repair
Gene co-expression module in Goblet cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
SUPT16H (FACT complex, histone chaperone for transcription-coupled nucleosome remodeling), PRKDC (DNA-PKcs, DNA DSB repair and V(D)J but also replication-associated), NAP1L1 (nucleosome assembly protein), PARP1 (DNA damage response/chromatin), CBX5 (HP1alpha, heterochromatin), SMC3 and SMC1A (cohesin complex), PSIP1 (LEDGF, chromatin-associated transcription/DNA repair), PPM1G (chromatin-associated phosphatase). This module centers on chromatin remodeling, nucleosome assembly, cohesin, and DNA repair — a chromatin/genome maintenance program. Neighbor context (cell cycle modules M49, M51, M80) supports this being a chromatin regulation program active in cycling or DNA-repair-engaged cells.
Genes
CBX5, HACD3, NAP1L1, PARP1, PPM1G, PRKDC, PSIP1, SMC1A, SMC3, SUPT16H
Most correlated modules
- Replication Fork Checkpoint · correlation 0.84
- Mitochondrial Chaperone · correlation 0.84
- MCM Replication Licensing · correlation 0.82
- hnRNP RNA Processing · correlation 0.80
- S-phase DNA Replication · correlation 0.79
- Spliceosome Assembly · correlation 0.73
- CCT Chaperonin Complex · correlation 0.70
- S/G2 Preparation · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.