S/G2 Preparation
Gene co-expression module in Goblet cells
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes TMPO (lamina-associated), LMNB1 (lamin B1, nuclear envelope), SMC2 (condensin complex), DTYMK (thymidylate kinase, DNA synthesis), HMGN2 (chromatin remodeling), UBE2T (DNA repair E2 ubiquitin ligase), MIS18A/MIS18BP1 (centromere licensing), TUBA1B/TUBB (tubulin), LSM3/LSM5 (RNA splicing), EXOSC8 (exosome). This module captures S/G2 preparation programs: nuclear envelope dynamics, centromere establishment, DNA replication support, and cytoskeletal readiness. MIS18A and MIS18BP1 are specifically involved in centromere priming before mitosis. TMPO and LMNB1 mark nuclear lamina disassembly/remodeling. Coherence is core. Neighbors are all cell cycle modules (M79, M42, M25, M62, M43), strongly supporting a cell cycle classification. The slight increase at remission in UC may reflect restored proliferation of goblet progenitors.
Genes
DTYMK, EXOSC8, HMGN2, LMNB1, LSM3, LSM5, MIS18A, MIS18BP1, SMC2, TMPO, TUBA1B, TUBB, UBE2T
Most correlated modules
- Mitotic Proliferation · correlation 0.92
- FOXM1-driven G2/M · correlation 0.91
- Chromosome Segregation · correlation 0.89
- Spliceosome Assembly · correlation 0.87
- Mitotic Spindle Assembly · correlation 0.85
- Chromatin Organization · correlation 0.82
- G2/M Cyclin Program · correlation 0.82
- CCT Chaperonin Complex · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.