Mitochondrial Biogenesis
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
ATP5F1D is a Complex V (ATP synthase) subunit; MRPL12 is a mitochondrial ribosomal protein; TIMM13 is part of the TIM23 mitochondrial import complex; CHCHD10 is a mitochondrial intermembrane space protein linked to respiratory chain organization; CISD3 is a mitochondrial iron-sulfur protein. GADD45GIP1 (GADD45GIP1/PCNA-I1) is a stress response/mitochondrial gene. MIF is a cytokine but also has mitochondrial functions. CYBA encodes p22-phox (NOX2 complex), involved in ROS/oxidative defense. The module decreases with both UC and CD inflammation and is strongly coherent. Despite a few non-canonical members, the dominant program is mitochondrial function/OxPhos, consistent with the broader neighborhood. The mix of mitochondrial ribosome, import machinery, and ATP synthase genes suggests a general mitochondrial maintenance/biogenesis program.
Genes
ARL6IP4, ATP5F1D, CHCHD10, CISD3, CYBA, GADD45GIP1, METTL26, MIF, MRPL12, MZT2B, TIMM13, TMEM160
Most correlated modules
- Mitochondrial OxPhos · correlation 0.77
- Electron Transport Chain · correlation 0.72
- Mitochondrial Biogenesis · correlation 0.70
- Mitochondrial Chaperone · correlation 0.68
- Pyroptosis Stress Response · correlation 0.65
- Mitochondrial OxPhos · correlation 0.63
- SR Splicing Factors · correlation 0.63
- Nucleotide Metabolism Stress · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.