NFKBIZ — NFKB inhibitor zeta

NFKBIZ belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NFKBIZ's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	NF-kB Feedback Response TCR/AP1/NFKb pathway	ADGRE5, ARL5B, ATF3, CSRNP1, PPP1R15B, RASGEF1B, TIPARP, TNFAIP3 +2 more	View in SCUBA
Endothelial	Integrated Stress Response Stress	ARL5B, ATF3, CCNL1, CD83, CDKN1A, DDIT3, ICAM4, IRF1 +3 more	View in SCUBA
Enterocytes	Epithelial NF-kB response Inflammation	ATP10B, CASP1, CCL28, E2F3, FAM135A, GSKIP, INPP4B, LYN +4 more	View in SCUBA
Fibroblasts	NF-κB Immediate Early Inflammatory	ATF3, DNAJA1, DUSP1, HLA-E, HSPA8, IRF1, MAFF, NFKBIA +4 more	View in SCUBA
Gamma-delta T cells	NF-κB Activation Inflammation	DUSP5, GADD45A, HERPUD1, IL21R, KDM6B, MAFF, NAMPT, NFKB1 +13 more
Glial cells	DNA Damage Response Stress	BRD2, FAM53C, GADD45B, IER5, ING1, PABPC1, SRSF3, TUBB4B +1 more	View in SCUBA
Goblet cells	Nucleotide Metabolism Stress Stress	APRT, CEBPD, CYB5A, LY6E, NME3, PNKD, TYMP	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Lymphatic endothelial	NF-κB Inflammatory Activation Inflammation	BCL3, CD83, HIF1A, INSIG1, IPO7, IRF1, KDM6B, MAP3K8 +1 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	Immediate-Early Inflammatory Inflammatory	CXCL2, CXCL3, CXCL8, DUSP2, EGR1, EGR2, NFKBIA, OTUD1 +3 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation T cell maturation	BTG2, CCNL1, CD69, CD83, CHMP1B, CYCS, DNAAF2, DNAJA1 +7 more
Natural Killer cells	Integrated Stress Response Stress	FAM43A, IER2, IER5, MARCKSL1, NFKBIA, PMAIP1, PPP1R15A, PPP1R15B +1 more	View in SCUBA
Neutrophils	NF-κB Activation Inflammatory	EHD1, GRAMD1A, NBN, NFKB2, NFKBIA, PLAUR, PLEK, PLK3 +6 more
Smooth muscle cells	NF-kB Stress Response Stress	BHLHE40, CCNL1, FADS3, HSP90AB1, IER3, MIDN, PPP1R15A, THBS1 +1 more	View in SCUBA

About the gene

Synonyms	FLJ34463, INAP, MAIL
Chromosome	3: 101827991-101861022
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Activator, Repressor
Biological process	Transcription, Transcription regulation

Function

Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.