Pyroptosis Stress Response
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
GSDMD (gasdermin D, pyroptosis executioner) is a prominent hub alongside PSMC3 (proteasome), PAXX (DNA repair), CENPX (centromere), and ADAM15 (metalloprotease). The module is significantly upregulated in both UC and CD inflammation (delta +0.134 and +0.177 respectively), pointing to an inflammatory stress/cell death program. GSDMD is the canonical pyroptosis pore-forming protein activated downstream of inflammasomes. PSMC3 and CDC37 link to proteostatic stress. INF2 (inverted formin) and ADAM15 relate to cytoskeletal remodeling and cell shedding. The inflammation-associated upregulation and GSDMD centrality support a pyroptosis/inflammasome-related stress response in goblet cells during IBD.
Genes
ADAM15, AURKAIP1, CDC37, CENPX, COMTD1, DDX39A, EEF1D, GSDMD, INF2, NOP56, NUDT8, PAXX, PGP, PSMC3, TCF25
Most correlated modules
- Sterol Biosynthesis · correlation 0.74
- Metabolic Stress Response · correlation 0.74
- Proteostasis Housekeeping · correlation 0.70
- Mitochondrial Biogenesis · correlation 0.70
- UPR Chaperone Response · correlation 0.68
- Electron Transport Chain · correlation 0.67
- S-phase DNA Replication · correlation 0.65
- Mitochondrial Biogenesis · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.