NME3 — NME/NM23 nucleoside diphosphate kinase 3
NME3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NME3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Ribosome Mitochondrial & OxPhos | APEX1, APRT, EIF3M, EXOSC5, FAM162A, LSM7, MRPL24, MZT2A +10 more | |
| Goblet cells | Nucleotide Metabolism Stress Stress | APRT, CEBPD, CYB5A, LY6E, NFKBIZ, PNKD, TYMP | View in SCUBA |
| Macrophages | Efferocytosis Anti-inflammatory Lysosomal & pahgocytosis | ABHD12, ADGRG5, AIG1, AXL, CCS, CD101, CD1D, CD300A +18 more | View in SCUBA |
About the gene
| Synonyms | DR-nm23, NDPKC, NM23-H3 |
|---|---|
| Chromosome | 16: 1770320-1771561 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Nucleotide metabolism |
Function
Catalyzes the phosphorylation of ribonucleosides and deoxyribonucleoside diphosphates, other than ATP, into the corresponding triphosphates with ATP as the major phosphate donor. The ATP gamma phosphate is transferred to the nucleoside diphosphate beta phosphate via a ping- pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Inhibits granulocyte differentiation. May be required for ciliary function during renal development (By similarity). Independently of its kinase activity, facilitates mitochondrial tethering prior to membrane fusion through its direct membrane-binding and hexamerization. Implicated in repair of both single- and double-stranded breaks in DNA through its association with the ribonucleotide reductase complex (RNR complex) via its interaction with the histone acetyltransferase KAT5, this interaction enables recruitment of NME3 at DNA damage sites where it plays a role in the repair of DNA, independently of its kinase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.