PNKD — PNKD metallo-beta-lactamase domain containing
PNKD belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PNKD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Complex I Assembly Mitochondrial & OxPhos | AKR7A2, AP2S1, BLOC1S1, DCTN2, HSD17B10, LAMTOR2, MGMT, MRPL34 +13 more | |
| Goblet cells | Nucleotide Metabolism Stress Stress | APRT, CEBPD, CYB5A, LY6E, NFKBIZ, NME3, TYMP | View in SCUBA |
| Lymphatic endothelial | Metabolic Housekeeping Housekeeping | CAPNS1, CYB5R3, DMAC1, DUT, EID1, ESD, GNAI2, ISCU +5 more | View in SCUBA |
| Macrophages | Glycogen Metabolism Housekeeping | ARL2BP, BTF3L4, CAPN1, CD47, CRLS1, DCTD, DSTN, GLOD4 +24 more | View in SCUBA |
About the gene
| Synonyms | BRP17, DKFZp564N1362, DYT8, FKSG19, FPD1, KIAA1184, KIPP1184, MGC31943, MR-1, MR-1S, PDC, PKND1, TAHCCP2 |
|---|---|
| Chromosome | 2: 218269651-218346793 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
Function
Probable thioesterase that may play a role in cellular detoxification processes; it likely acts on a yet-unknown alpha- hydroxythioester substrate (Probable). In vitro, it is able to catalyze the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D- lactic acid at very low rate, though this reaction is not physiologically relevant in vivo
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.