NF-kB Inflammatory Signaling
Gene co-expression module in Goblet cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
This module shows mild but significant inflammation upregulation (delta ~0.18–0.22 in UC/CD). Hub genes are centered on NF-kB signaling and inflammatory transcription: TNFAIP3 (A20, NF-kB negative regulator), NFKB2 (NF-kB subunit), REL (c-Rel, NF-kB subunit), FOSL2 (AP-1 transcription factor), ZC3H12A (MCPIP1/Regnase-1, mRNA decay/NF-kB regulation), TSC22D3 (glucocorticoid-induced leucine zipper, anti-inflammatory), CD69 (activation marker), CXCR4 (chemokine receptor), VEGFA (angiogenic/hypoxia target), DUSP2 (MAPK phosphatase), IRF1 (interferon regulatory factor), DDX21 (RNA helicase, ribosome biogenesis), SLC3A2 (amino acid transporter), RGCC (cell cycle/apoptosis regulator). This is a coherent NF-kB/AP-1 inflammatory signaling module with negative feedback components (TNFAIP3, ZC3H12A, TSC22D3, DUSP2), characteristic of the immediate early inflammatory response in epithelial cells.
Genes
CD69, CXCR4, DDX21, DUSP2, FOSL2, IRF1, NFKB2, REL, RGCC, SLC3A2, TNFAIP3, TSC22D3, VEGFA, ZC3H12A
Most correlated modules
- Stress Survival Response · correlation 0.65
- DUOX2 Epithelial Inflammation · correlation 0.59
- NF-κB Stress Response · correlation 0.48
- Nucleotide Metabolism Stress · correlation 0.47
- EGF-Driven Wound Repair · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.