POLR2K — RNA polymerase II, I and III subunit K
POLR2K belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POLR2K's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Proteasome Degradation Housekeeping | ARPP19, CLTA, GNG5, HSBP1, NDUFB4, POLR2J, PSMB2, PSMB3 +2 more | View in SCUBA |
| Gamma-delta T cells | RNA Binding/Splicing RNA processing & translation | AIMP1, ATP11B, C1orf43, CCT2, DEDD2, DGKD, ENSA, ENY2 +18 more | |
| Goblet cells | Basal Transcription Housekeeping | ACTB, ACTG1, CALM2, DYNLL1, ELOC, ENY2, GTF2A2, LSM8 +2 more | View in SCUBA |
| Innate lymphoid cells | ILC Survival Residency Gut residency | ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more | View in SCUBA |
| Natural Killer cells | TGF-beta Repression DNA regulation & transcription | BZW1, GTF2B, HBP1, ODC1, SKIL, SKP1, SPTY2D1, UBE2D3 | View in SCUBA |
About the gene
| Synonyms | RPB10alpha, RPB12 |
|---|---|
| Chromosome | 8: 100150623-100154003 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins |
| Biological process | Transcription |
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.