G2/M Cyclin Program
Gene co-expression module in Goblet cells
| Category | Cell cycle |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes: CCNB1 (cyclin B1, G2/M), CCNB2 (cyclin B2, G2/M), HMMR (spindle assembly), CDC20 (APC/C activator, metaphase-to-anaphase), PTTG1 (securin, separase inhibitor), DLGAP5 (spindle), CENPF (kinetochore fiber), NEK2 (centrosome kinase, G2/M), PRR11 (G2/M regulator), SAPCD2 (mitotic), CENPE (kinetochore motor), ARL6IP1 (ER/mitosis), TROAP (astral microtubule), CEP55 (cytokinesis/abscission). All core. This module is a classic G2/M cyclin-driven program anchored by CCNB1/CCNB2, with APC/C activation (CDC20, PTTG1) marking metaphase-to-anaphase transition. Distinguished from M62 by dominance of cyclin B complex and APC/C targets rather than general proliferation markers.
Genes
ARL6IP1, CCNB1, CCNB2, CDC20, CENPE, CENPF, CEP55, DLGAP5, HMMR, NEK2, PRR11, PTTG1, SAPCD2, TROAP
Most correlated modules
- Mitotic Spindle Assembly · correlation 0.96
- Mitotic Proliferation · correlation 0.95
- Chromosome Segregation · correlation 0.88
- S/G2 Preparation · correlation 0.82
- Chromatin Organization · correlation 0.69
- Basal Transcription · correlation 0.67
- FOXM1-driven G2/M · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.