Mitotic Proliferation
Gene co-expression module in Goblet cells
| Category | Cell cycle |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes: BIRC5 (survivin, chromosomal passenger/anti-apoptosis), RACGAP1 (RhoGAP, cytokinesis), TPX2 (Aurora A activator, spindle assembly), TOP2A (topoisomerase II, DNA decatenation), MKI67 (Ki67, proliferation marker), PBK (TOPK kinase, mitosis), CCNA2 (cyclin A2, S/G2), KIF20B (kinesin, cytokinesis). All core. This module is dominated by canonical proliferation/M-phase markers (MKI67, TOP2A, CCNA2) and cytokinesis regulators (RACGAP1, KIF20B, BIRC5). It represents the most general 'proliferating cell' signature in this cluster, with strong mitotic identity. Neighbors confirm cell cycle context.
Genes
BIRC5, CCNA2, KIF20B, MKI67, PBK, RACGAP1, TOP2A, TPX2
Most correlated modules
- Mitotic Spindle Assembly · correlation 0.97
- Chromosome Segregation · correlation 0.96
- G2/M Cyclin Program · correlation 0.95
- S/G2 Preparation · correlation 0.92
- FOXM1-driven G2/M · correlation 0.83
- Chromatin Organization · correlation 0.71
- Basal Transcription · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.