Goblet Cell Differentiation
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
KLF4 is the master transcription factor for goblet cell terminal differentiation in the colon. ELF3 is an ETS-family TF essential for intestinal epithelial identity. CLDN4 marks mature epithelial tight junctions. KLF3 is a related KLF family repressor. TOB1 is anti-proliferative. PPP1R15A (GADD34) dephosphorylates eIF2α to restore translation after stress. RAB11FIP1 supports vesicle trafficking relevant to mucus secretion. High expression (92% positive), moderately down in UC inflammation and up in remission — consistent with a core goblet cell identity/differentiation program.
Genes
CLDN4, EIF1, ELF3, KLF3, KLF4, MIDN, PPP1R15A, RAB11FIP1, TOB1
Most correlated modules
- NF-κB Stress Response · correlation 0.88
- Immediate Early Gene · correlation 0.82
- Stress Chromatin Remodeling · correlation 0.80
- Notch Target Response · correlation 0.72
- Stress Survival Response · correlation 0.64
- BMP Signaling Response · correlation 0.62
- EGF-Driven Wound Repair · correlation 0.51
- Notch Secretory Specification · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.