Stress Chromatin Remodeling
Gene co-expression module in Goblet cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
GADD45A is a canonical DNA damage/stress response gene; PMAIP1 (NOXA) is a pro-apoptotic BH3-only protein activated by stress; KDM6B (JMJD3) is a H3K27me3 demethylase that activates stress and inflammatory gene programs epigenetically; ZFAND5 binds ubiquitin and participates in proteasomal stress responses; YBX3 is an RNA-binding protein involved in stress granule formation; ZFP36L2 destabilizes mRNAs; SOX9 marks intestinal progenitors; ETS2 is a stress/inflammatory TF. The module represents a stress-activated chromatin remodeling and cell fate checkpoint program, mildly suppressed in inflammation. Neighbor to M52 and M66 stress/IEG modules.
Genes
ETS2, GADD45A, KDM6B, PMAIP1, SDC4, SOX9, YBX3, ZBTB7A, ZFAND5, ZFP36L2
Most correlated modules
- NF-κB Stress Response · correlation 0.85
- Goblet Cell Differentiation · correlation 0.80
- Immediate Early Gene · correlation 0.71
- Stress Survival Response · correlation 0.69
- Notch Target Response · correlation 0.61
- EGF-Driven Wound Repair · correlation 0.60
- Heat Shock Response · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.