NF-κB Stress Response

Gene co-expression module in Goblet cells

View this module in SCUBA

Why this annotation

NR4A1 (Nur77) is a nuclear receptor activated by inflammatory and stress signals; ATF3 is a stress-inducible bZIP TF; NFKBIA encodes IκBα, the primary NF-κB inhibitor (induced as negative feedback); MAFF is a small Maf bZIP TF involved in oxidative/electrophilic stress response; IER3 is an NF-κB target immediate early gene; ZFP36 (TTP) destabilizes inflammatory mRNA; RHOB mediates stress-activated cytoskeletal responses; EGR3 is a stress-responsive zinc finger TF; CCNL1 is a cyclin involved in transcriptional regulation. Together these form a stress-activated NF-κB/ATF transcriptional feedback module, distinct from the pure AP-1 IEG module (M66) but co-expressed as a neighbor.

Genes

ATF3, CCNL1, EGR3, IER3, MAFF, MYADM, NFKBIA, NR4A1, RHOB, ZFP36

Most correlated modules

• Immediate Early Gene · correlation 0.89
• Goblet Cell Differentiation · correlation 0.88
• Stress Chromatin Remodeling · correlation 0.85
• Stress Survival Response · correlation 0.72
• Notch Target Response · correlation 0.67
• Heat Shock Response · correlation 0.61
• EGF-Driven Wound Repair · correlation 0.52
• NF-kB Inflammatory Signaling · correlation 0.48

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.